Global Bone Grafts and Substitutes Market By Material Type (Allograft and Synthetic), By Application (Craniomaxillofacial, Foot & Ankle, Spinal Fusion, Dental, Joint Reconstruction and Long Bone), By Region and Companies - Industry Segment Outlook, Market Assessment, Competition Scenario, Trends and Forecast 2023-2032

Bone Grafts Markets Overview:

Global bone graft markets were valued at USD 3,500 million in 2021. They are expected to grow at a 5.8% compound annual growth rate (CAGR), from 2023 to 2032.

The rising incidence of joint and bone disorders is one of the main factors driving the market’s growth. Around 200 million women are affected by osteoporosis worldwide. The market for substitutes and bone grafts will also grow over the forecast period due to the increasing demand for them. Bone grafts have been widely used in orthopedic surgery. These surgeries are considered elective and many elective procedures were postponed during the COVID-19 epidemic. The demand for orthopedic devices, such as bone grafts and substitutes, decreased dramatically.

Global Bone Grafts and Substitutes Market Scope:

Application Analysis

In 2021, the spinal fusion segment accounted for more than 62% of all revenue. The market can be divided into spinal fusion, long bone, foot and ankle, and craniomaxillofacial and dental. This growth can be attributed largely to the increasing use of bone graft material for spondylosyndesis. Corrective surgery is also needed due to the increasing number of geriatric patients with orthopedic conditions. This will increase the market growth. The World Health Organization predicts that the geriatric population will double between 2023 to 2032, from 12% to 25%. The segment is expected to see lucrative growth opportunities due to the increasing use of grafts in dental procedures.

The grafts can be used to support bone growth and healing. Market growth is expected to be boosted by increasing acceptance of advanced dental implant surgery techniques, such as bone regeneration and bone transplants. The market is also experiencing a growing demand for bone substitutes and grafts due to the increasing success rate of dental implants. According to Trend Statistics, there has been a 6.3% increase in dental implant procedures since last year. Due to an increase in hip and knee replacements, the joint reconstruction segment will see steady growth. The center for orthotic and neurological care research estimates that the number of total knee replacement procedures will increase by 673% to 3.6 million annually by 2030. In the coming years, there will be significant growth in long bone segments.

Material Type Analysis

The market leader in allografts was the segment that accounted for more than 56.3% of global revenue in 2021. The allograft market can be further divided into two segments: the demineralized and the other. Allografts are becoming more popular due to their osteoconductivity and immediate structural support. They don’t require any additional surgery bone which speeds up wound healing and reduces the time it takes to complete the surgery. They are used most often in the spine, hip, knee, and other areas. You can easily find demineralized bone matrixes in many sizes and shapes such as chips and pellets.

They also have osteoinductive and osteoconductive properties which increase their market appeal. Over the forecast period, synthetic segments are expected to experience significant growth. The products are more biocompatible, less likely to transmit disease, and have a higher acceptance rate among patients than allografts. The synthetic segment can be further divided into composites and polymers, ceramics, polymers, and BMP. Ceramics dominated the market in 2021. The body absorbs ceramic material easily, maintaining bone position and reducing the risk of disease transmission. The procedure is also more popular because it takes less time, results in less blood loss, and requires less pain.

Key Market Segments:

Material Type

• Allograft
• Synthetic
  • Ceramics
  • Composites
  • Bone Morphogenic Proteins (BMP)
  • Polymers

Application

• Craniomaxillofacial
• Foot & Ankle
• Spinal Fusion
• Dental
• Joint Reconstruction
• Long Bone

Market Dynamics:

The production of these devices was also affected by extended factory closings by various market players. The infection rate has been declining since the third quarter of 2021. This will slow down the production cycle and increase the production of bone substitutes and grafts. Many countries have also begun to loosen their restrictions on healthcare facilities, which has led to a number of countries opening up to the world. This will increase demand for orthopedic surgery and restore the market’s growth. Market growth will also be fueled by the launch of biocompatible synthetic transplants.

To gain greater market share, market players are investing in developing such grafts. McGill University, for example, developed a multilayered biocompatible and toughened bone graft in October 2019 to treat large bone defects. This graft was expected to give them a competitive advantage over other market players. The market is also growing due to the rising demand for dental bone transplants and technological advances. Minim Invasive Surgery in 2018 stated that minimally invasive techniques are being used to treat a wide range of bone disorders. According to the report, approximately 400,000 cases of spinal fusion were performed in the U.S. each year. These factors will likely have a positive impact on the market’s growth over the next few years. Market growth is also being driven by the increasing demand for biocompatible bone grafts that can reduce adverse reactions. Diverse players in the market are constantly investing to develop new products that have better bioactivity, biocompatibility, and other suitable mechanical properties.

Regional Analysis:

North America was the dominant market, accounting for about 40.7% of global revenue in 2021. The key factors driving the regional market growth are increasing awareness about the availability of innovative products and a well-developed healthcare system. Due to the increasing number of cases of orthotic disease and trauma-related injuries, the U.S. market is the most important in North America. The forecast period for the Asia Pacific will see a lot of growth. This is due to favorable government initiatives and rising medical tourism.

However, only a handful of countries allow for adoption due to strict regulatory guidelines. South Korea’s Food and Drug Administration (KFDA) must approve the product before it can be sold. The Therapeutic Goods Administration (TGA) regulates products in Australia. Japan has strict regulations that restrict foreign players from entering the country. Despite this, the Japan allograft market has been approved in 2019 and is expected to grow in the Asia Pacific over the next ten years.

Key Regions and Countries covered in the report:

• North America
  • US
  • Canada
  • Mexico
• Europe
  • Germany
  • UK
  • France
  • Italy
  • Russia
  • Spain
  • Rest of Europe
• APAC
  • China
  • Japan
  • South Korea
  • India
  • Rest of Asia-Pacific
• South America
  • Brazil
  • Argentina
  • Rest of South America
• MEA
  • GCC
  • South Africa
  • Israel
  • Rest of MEA

Market Share Analysis:

There are many small and large businesses operating in the industry. This market is highly competitive and is dominated mainly by major players. To increase their revenues, key players are focusing on innovative strategies such as mergers and acquisitions. To increase its cervical portfolio, and expand growth opportunities, NuVasive purchased Simplify Medical in February 2021.

Key Market Players:

• Nuvasive, Inc.
• AlloSource
• Zimmer Biomet
• DePuySynthes, Inc.
• Orthofix Holdings, Inc.
• Baxter
• OST Development
• Smith & Nephew
• Biobank
• Other Key Players

For the Bone Grafts and Substitutes Market research study, the following years have been considered to estimate the market size: